Thanks to everyone for your suggestions.The consensus is clearly to stick with two boilers. This surprises me because I had assumed one boiler would be much cheaper to run than two of the same total output. That's good to know given that replacing one at a time is the cheaper initial option.So it looks like the way forward is to replace the one boiler and get the system checked over. The money saved on the more radical options can go to better insulation. This is tricky as it's a listed building - I have plenty of loft insulation but walls are solid stone 2 - 3 ft thick and no chance of double glazing. Also surprisingly big windows for such an old house, on 2 or even 3 sides of most rooms. I think a programme of window repair and secondary glazing is called for.BTW - the two current systems are on separate controls so the part we use mostly during the day goes off in the evening and vice versa. And we do have TRVs set to minimum in unused rooms. And in addition to the £2500 oa gas we spend about £600 pa on logs. No, we're not nudists - we wear jumpers!
You definitely would need some energy advice. Seems your setup is not very good. 2-3ft walls are relatively good insulators anyway.
And do not get put off from double glazing. Of course you can have it. I live in a listed building myself and we got double glazing.It might not be the cheapest option but some good joiners/glazers can make replicas of your windows just with double glazing.Sometimes even double glazing can get fitted into the existing frames.
As for the insulation they have replaced the plasterboard by foam back plasterboard. Makes quite a difference. As much as for draught proofing as well as for making the rooms heating up quickly.
With your gas usage I would first look at the UFH. As plenty of them have been fitted as UTFH (under the floor heating). Been replacing a few of them now already with little or no insulation under the pipes/screed.
In one scenario we fitted once trench heating round the walls to create a hot air curtain as a shield against cold draughts from the walls combined with UFH in the rest of the floor area. Walls were meant to be left coarse looking with no insulation inside or outside.
The other thing is trying to switch things off to much can sometimes be a costly mistake as you turn your inside walls into outside walls and enlarge the surface in addition. The radiators in the remaining rooms then have to fight against heat losses they have not been specified for.
If it needs be then make sure that unused rooms are adjoining and temperatures increase towards used rooms.Further it can sometimes (lets say quite often) safe to keep a constant background heat at all times to prevent cold draught effects from walls which require you to heat higher than normal to still be comfortable.
Rule of thumb is: If the wall temperature differs more than 3 degC from the air temperature in the room you do get this "wind chill effect". Most people describe it as the walls radiating cold.
Problem really is, without enough information it is guessing. And even with enough information it is sometimes a bit playing around with monitoring to find a better setup.