Holes always weaken walls to some extent. May be significant, may not be depending on the circumstances.
Let's see some photos of your work. I'd like to see a 50cm hole thorough a brick+block cavity exterior load-bearing wall left open and unreinforced as the finished work, please. And if it's "Absolutely safe" you'll doubtless be able to produce evidence of building control approval for the work too.
So chuck years ago when fitting the 300mm x 300mm square balanced flue appliances you kindly fit a lintel in for them did you?