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One. I also have a Drayton TRV, a Regis TRV, and a 4th that looks like the Honeywell but I'm not sure because it's somewhat hard to see (behind a chest of drawers).

Six rads total in the house. Four TRV. Two manual.
 
So before you made your last post, I went around and turned down, although not off, several of the TRVs. Lo and behold, it worked. The previously-cold rad is now putting out at least some heat. I am going to go and turn down the manual valve upstairs as well, since it's plenty warm up there.

Does this mean, basically, the boiler isn't of sufficient size, or the water flow through the house isn't efficient enough, to heat everything at once, so the hot water stalls in the system before reaching the badly-performing rad?
 
So before you made your last post, I went around and turned down, although not off, several of the TRVs. Lo and behold, it worked. The previously-cold rad is now putting out at least some heat. I am going to go and turn down the manual valve upstairs as well, since it's plenty warm up there.

Does this mean, basically, the boiler isn't of sufficient size, or the water flow through the house isn't efficient enough, to heat everything at once, so the hot water stalls in the system before reaching the badly-performing rad?

Sounds more like a balancing issue, so some rads are taking out too much heat and not leaving enough heat in the water for your problem rad. By balancing (i.e. in this case reducing) the flow through the other radiators your problem rad has heated up. With a bit more tweaking you should be able to get this to work properly.
 
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