I don't see where the size of the heat exchanger factors into the calculation above. Forgetting about the radiators for a moment, at a lower tank temperature the size of the heat exchanger needs to increase to maintain the desired flow and temperature of DHW.IF only using HW, then, theoretically, a store temp of 48.6C will give ~ 10 LPM at 48C with a return of 25C (with a reduced pump flow of 18.6LPM) see below, but its not as simple as that because the rad return temperatures will influence the return since it will be mixed with that 25C and also the total energy required will increase due to the rad requirements, so realistically you might require a store temp of 60C which should give a output of 50kw, 30kw for HW + say 20kw for rads.
If installing new rads, I would aim for T30 rads, a factor of X1.9 of a T50, and I would suggest calculate each room energy requirement separately in watts, multiply this by a factor of say 2, so if you require say a 2500 watt rad for a room, you look up your brochure for 5000 watt rad (T50) and you can then pick the appropriate rad, single, double, or triple and see how it might look in each room.
The question is how low can you go with a 165Kw exchanger?